NOTCH1
NOTCH1geneNOTCH1 signaling controls endothelial biology and vascular calcification, contributing to plaque stability and coronary thrombosis risk.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleNotch signaling regulates endothelial function, angiogenesis, and vascular calcification in atherosclerotic disease.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000148400
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I45
C — confounder / Type-II88
A — assay feasibility52
E — evidence strength32
T1DI (composite)5
Specificity differential (R−C)-43
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(2)
- Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.Arteriosclerosis, thrombosis, and vascular biology · 2026 · PMID 41924874 · doi
- Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.Journal of molecular and cellular cardiology · 2018 · PMID 30219518 · doi
Omics datasets(1)
- GSE318807GEORegulatory Elements Harboring Common Coronary Artery Disease Risk Variants Control Endothelial TSPAN14 Expression and NOTCH1 Signaling