CoronaryAtlas logo
CoronaryAtlas
NADPH oxidase 4
Pathway / Myocardial injury (shared endpoint)

NADPH oxidase 4

NOX4gene

NOX4-driven NADPH oxidase activity amplifies oxidative stress and myocardial injury during ischemia-reperfusion.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleNADPH oxidase mediates oxidative stress and ROS generation in ischemia-reperfusion injury.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000086991

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
60
A — assay feasibility
52
E — evidence strength
50
T1DI (composite)
7
Specificity differential (R−C)-45
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 9 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)