Nuclear receptor subfamily 3 group C member 2 (mineralocorticoid receptor)
NR3C2geneMineralocorticoid receptor activation drives sodium retention, hypertension, and vascular/cardiac remodeling; increases thrombotic and arrhythmic risk.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleAldosterone signaling; electrolyte/fluid homeostasis regulator.
Druggability
DruggableYes
Known drugs / candidates17
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000151623
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.603
Open Targets association (myocardial_infarction)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.