NRAS

NRASgene

NRAS modulates pathways governing cardiomyocyte ischemia and injury response during acute MI.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleNRAS regulates ischemic signaling cascades affecting myocardial survival.

Also acts inVascular inflammation

Druggability

DruggableYes

Known drugs / candidates1

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000213281

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-24.9

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable