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NRAS
Pathway / Myocardial injury (shared endpoint)

NRAS

NRASgene

NRAS modulates pathways governing cardiomyocyte ischemia and injury response during acute MI.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleNRAS regulates ischemic signaling cascades affecting myocardial survival.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000213281

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
46
C — non-Type-I
63
A — assay feasibility
52
E — evidence strength
26
T1DI (composite)
6
Specificity differential (R−C)-17.2
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)