NRF1

NRF1protein

A transcription factor regulating nuclear respiratory genes associated with CAD risk but acting on a systemic metabolic axis.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencelow

RationaleTranscription factor regulating CAD-related genes; not a plaque-specific mechanism anchor.

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

Oxidized LDL Induces Pro-Inflammatory Transcriptomic and Epigenomic Responses in Human CD4T Cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · PMID 41707046 · doi