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Neuregulin-1
Pathway / Endothelial activation & erosion

Neuregulin-1

NRG1protein

Neuregulin-1 activates ERBB2/ERBB4 signaling in endothelial cells, suppressing endothelial-to-mesenchymal transition and stabilizing vascular integrity.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleNRG-1/ERBB signaling suppresses EndMT and protects endothelial barrier.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000157168

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
62
A — assay feasibility
68
E — evidence strength
23
T1DI (composite)
5
Specificity differential (R−C)-38.2
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)

Clinical trials(1)