Pathway / Endothelial activation & erosion

Neuregulin-1

NRG1protein

Neuregulin-1 activates ERBB2/ERBB4 signaling in endothelial cells, suppressing endothelial-to-mesenchymal transition and stabilizing vascular integrity.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencemedium

RationaleNRG-1/ERBB signaling suppresses EndMT and protects endothelial barrier.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000157168

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-42.6

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)

Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition.
BioMed research international · 2019 · PMID 31317035 · doi

Clinical trials(1)

Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study
NCT04391491 · COMPLETED · Neuregulin-1β level in plasma