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Oxidative stress responsive gene 2
Pathway / Endothelial activation & erosion

Oxidative stress responsive gene 2

OSGIN2gene

OSGIN2 upregulation indicates endothelial dysfunction and oxidative stress in plaque erosion-prone lesions.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleEndothelial stress gene induced by oxidative stress and endothelial injury in erosion.
Also acts inVascular inflammation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000164823

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — confounder / Type-II
—
A — assay feasibility
52
E — evidence strength
15
T1DI (composite)
5
Specificity differential (R−C)+16.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuren/a
6hypertensive emergencyn/a
7high-demand / peri-operative stressn/a
Coverage: 0/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 1 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)