Pathway / Endothelial activation & erosion

Oxidative stress responsive gene 2

OSGIN2gene

OSGIN2 upregulation indicates endothelial dysfunction and oxidative stress in plaque erosion-prone lesions.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencehigh

RationaleEndothelial stress gene induced by oxidative stress and endothelial injury in erosion.

Also acts inVascular inflammation

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000164823

Type I vs non-Type I discrimination

ScoresIndeterminate

R — rupture / Type-I

C — non-Type-I

—

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+66.7

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

2sepsis / systemic inflammationn/a

2anemia / acute blood lossn/a

2hypovolemia / dehydrationn/a

2tachyarrhythmian/a

2hypoxemia / respiratory failuren/a

2hypertensive emergencyn/a

2high-demand / peri-operative stressn/a

3sudden cardiac deathn/a

4aPCI-related periproceduraln/a

4bstent thrombosisn/a

4cin-stent restenosisn/a

5CABG-relatedn/a

Coverage: 0/12 axes with evidence

Tier: deep-scored (abstract-extracted). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion.
Cardiovascular research · 2023 · PMID 36804807 · doi