Oncostatin M

OSMprotein

OSM drives macrophage and smooth-muscle activation in atherosclerotic plaque; elevated in acute inflammation.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleIL-6-family cytokine; plaque inflammation and vascular remodeling.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000099985

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — non-Type-I

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-19.8

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

No non-Type-I axis evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

GWAS associations

Traits: myocardial infarction

Literature evidence(0)

No direct literature mentions harvested; included via genetic/target evidence.