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P2X7 Receptor
Pathway / Plaque inflammation

P2X7 Receptor

P2RX7protein

P2X7 receptor activation on neutrophils and macrophages amplifies plaque inflammation through inflammatory mediator release.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleP2X7 drives neutrophil activation and sLOX-1 release, key inflammatory amplification in plaque.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000089041

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
45
C — non-Type-I
65
A — assay feasibility
72
E — evidence strength
27
T1DI (composite)
8
Specificity differential (R−C)-20.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)