Pathway / Off-pathway / systemic markers

Poly(ADP-ribose) polymerase 12

PARP12gene

PARP12 regulates interferon signaling and antiviral response; systemic inflammation marker without specific plaque involvement.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencelow

RationaleInnate immune regulator; no direct atherothrombotic mechanism.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000059378

Type I vs Type II discrimination

ScoresType-II-associated

R — rupture / Type-I

—

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-43.3

Confounder panel (Type-II drivers)

1sepsis / systemic inflammationmag 2

2anemia / acute blood lossn/a

3hypovolemia / dehydrationn/a

4tachyarrhythmiamag 2

5hypoxemia / respiratory failuremag 2

6hypertensive emergencyn/a

7high-demand / peri-operative stressmag 1

Coverage: 4/7 confounders with evidence

Tier: deep-scored (abstract-extracted) · 15 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

GWAS associations

Traits: myocardial infarction

Literature evidence(0)

No direct literature mentions harvested; included via genetic/target evidence.