PDK1

PDK1protein

PDK1 shifts myocardial metabolism toward glycolysis during ischemia, limiting oxidative stress and cardiomyocyte necrosis.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationalePyruvate dehydrogenase inhibitor promoting glycolysis in ischemic cardiomyocytes; reduces post-MI remodeling.

Druggability

DruggableYes

Known drugs / candidates1

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000152256

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-43.5

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)