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Phosphatase and actin regulator 1
Pathway / Endothelial activation & erosion

Phosphatase and actin regulator 1

PHACTR1gene

Phosphatase regulating actin dynamics in endothelial dysfunction, arterial calcification, and fibrous-cap degradation driving plaque vulnerability and rupture.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleActin cytoskeleton in endothelial/SMC contraction; calcification and plaque vulnerability via multiple mechanisms.
Also acts inCap degradation / rupture, Vascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000112137

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.524
Open Targets association (myocardial_infarction)
17
GWAS associations
Traits: myocardial infarction

Literature evidence(5)