PIK3R3

PIK3R3gene

PIK3R3 downstream of ADTRP inhibits monocyte-endothelial adhesion and recruitment, suppressing plaque-destabilizing inflammation.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleADTRP effector inhibiting monocyte adhesion via phosphoinositide-3-kinase signaling; suppresses leukocyte tethering.

Also acts inPlatelet activation

Druggability

DruggableYes

Known drugs / candidates24

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000117461

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable