PIM3
PIM3genePIM3 kinase promotes endothelial dysfunction and vascular inflammation, contributing to atherosclerotic plaque destabilization and coronary thrombosis.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleSerine/threonine kinase regulating endothelial dysfunction and inflammatory responses.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000198355
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- miR-1307-5p mediates endothelial dysfunction and inflammation induced by acute coronary syndrome by targeting PIM3.Journal of cardiothoracic surgery · 2026 · PMID 42106777 · doi