Phospholipase A2 Group IIE
PLA2G2EgeneSecreted phospholipase regulating lipoprotein remodeling and lipid metabolism in atherosclerotic lesion formation.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationalesPLA-IIE involved in metabolic regulation and lipid remodeling.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000188784
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Group IID, IIE, IIF and III secreted phospholipase As.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018 · PMID 30905347 · doi