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Phospholipase A2 group III
Pathway / Plaque inflammation

Phospholipase A2 group III

PLA2G3gene

Phospholipase A2 isoform generating pro-inflammatory lipid mediators and oxidized phospholipids during atherosclerotic plaque inflammation.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalesPLA-III implicated in atherosclerosis; generates lipid mediators and oxidized phospholipids in plaque.
Also acts inLipid entry/oxidation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000100078

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)