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Lipoprotein-associated Phospholipase A2
Pathway / Plaque inflammation

Lipoprotein-associated Phospholipase A2

PLA2G7protein

Lp-PLA2 generates inflammatory mediators from oxidized lipids within atherosclerotic plaques, promoting destabilization and rupture.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleLp-PLA2 hydrolyzes oxidized phospholipids in oxLDL; drives plaque inflammation and rupture risk.
Also acts inLipid entry/oxidation, Platelet activation
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000146070

Type I vs non-Type I discrimination

ScoresIndeterminate
R — rupture / Type-I
—
C — non-Type-I
44
A — assay feasibility
72
E — evidence strength
48
T1DI (composite)
12
Specificity differential (R−C)-29.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 1
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 1
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedn/a
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 5 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.001
Open Targets association (NSTEMI)

Literature evidence(24)

Clinical trials(4)