PLPP3

PLPP3protein

PLPP3 regulates lysophospholipid signaling and endothelial quiescence; critical for hemodynamic mechanosensing and endothelial stability.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencemedium

RationaleLipid phosphatase; endothelial barrier maintenance and mechanosensing.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000162407

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

0.447

Open Targets association (myocardial_infarction)

GWAS associations

Traits: myocardial infarction