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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha
Pathway / Myocardial injury (shared endpoint)

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha

PPARGC1Aprotein

PGC-1α protects cardiomyocytes through mitochondrial biogenesis and oxidative stress reduction.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMitochondrial biogenesis regulator; cardiomyocyte metabolic protection during ischemia.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000109819

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
33
C — non-Type-I
75
A — assay feasibility
68
E — evidence strength
30
T1DI (composite)
6
Specificity differential (R−C)-41.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(3)

Omics datasets(1)