Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha
PPARGC1AproteinPGC-1α protects cardiomyocytes through mitochondrial biogenesis and oxidative stress reduction.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMitochondrial biogenesis regulator; cardiomyocyte metabolic protection during ischemia.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000109819
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I33
C — confounder / Type-II87
A — assay feasibility68
E — evidence strength32
T1DI (composite)5
Specificity differential (R−C)-53.9
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(3)
- Cardioprotective effects of the jiming formula on myocardial metabolism in Mice with myocardial infarction via the AMPK/SIRT1/PGC-1α pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025 · PMID 40220403 · doi
- Hypericin attenuates myocardial ischemia-reperfusion injury by enhancing mitochondrial energy metabolism via AMPK/PGC-1α signaling pathway.Tissue & cell · 2025 · PMID 40848413 · doi
- Mitochondrial metabolic remodeling and multi-omics profiling identify plasma biomarkers of myocardial infarction.Journal of molecular and cellular cardiology plus · 2025 · PMID 41399465 · doi
Omics datasets(1)
- GSE298270GEOCRISPR/Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function and recovery after myocardial infarction