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PPFIA4
Pathway / Off-pathway / systemic markers

PPFIA4

PPFIA4gene

PPFIA4 is a protective gene linked to supernormal coronary-artery phenotype; regulates cell-cell adhesion and endothelial integrity via developmental mechanisms.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleSupernormal coronary phenotype; adhesion/junction regulation, off-pathway.
Also acts inEndothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)