Peptidylprolyl Isomerase A (Cyclophilin A)

PPIAprotein

PPIA downregulation in acute MI reflects disruption of intracellular protein folding and cellular stress in ischemic myocardium.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleMI biomarker downregulated in acute MI; intracellular chaperone altered during cardiomyocyte damage.

Druggability

DruggableYes

Known drugs / candidates3

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000196262

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

0.326

Open Targets association (STEMI)