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Protein phosphatase 5
Pathway / Plaque inflammation

Protein phosphatase 5

PPP5Cprotein

Protein phosphatase 5 controls leukotriene B4 production by regulating 5-lipoxygenase phosphorylation, amplifying inflammatory cell recruitment to the plaque.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalePP5 regulates LTB4 synthesis, a potent neutrophil and platelet inflammatory mediator.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000011485

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)