PRMT9

PRMT9gene

PRMT9-mediated arginine methylation of PFKL and other substrates controls neutrophil activation and NET formation during coronary thrombosis.

Pathway placement

Cascade stepPlaque inflammation

Confidencelow

RationaleMethyltransferase regulating PFKL and NETosis in neutrophil inflammatory pathways.

Also acts inPlatelet activation

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000164169

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable