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Endothelial protein C receptor
Pathway / Endothelial activation & erosion

Endothelial protein C receptor

PROCRgene

PROCR encodes the endothelial protein C receptor, an antithrombotic and anti-inflammatory regulator whose expression is altered during endothelial dysfunction and plaque destabilization.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleAntithrombotic endothelial regulator; genetic variation associated with CAD; active on valve cusps during endothelial activation.
Also acts inCoagulation / thrombus
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000101000

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
79
C — confounder / Type-II
73
A — assay feasibility
52
E — evidence strength
31
T1DI (composite)
9
Specificity differential (R−C)+5.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.507
Open Targets association (myocardial_infarction)
1
GWAS associations
Traits: myocardial infarction

Literature evidence(5)