Proline/Serine-Rich Coiled-Coil 1
PSRC1geneA genetic locus influencing atherosclerotic plaque development and MI susceptibility, likely through lipid or metabolic pathways.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleAtherosclerosis and MI susceptibility locus; lipid pathway involvement.
Also acts inSystemic / off-pathway
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000134222
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.452
Open Targets association (myocardial_infarction)
3
GWAS associations
Traits: myocardial infarction
Literature evidence(2)
- Association of six genetic variants with myocardial infarction.International journal of molecular medicine · 2015 · PMID 25738804 · doi
- From genotype to phenotype in human atherosclerosis--recent findings.Current opinion in lipidology · 2013 · PMID 24005217 · doi