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COX-2
Pathway / Thromboxane amplification

COX-2

PTGS2gene

COX-2 catalyzes thromboxane-A2 and prostacyclin synthesis, driving platelet activation and inflammation in Type 1 MI.

Pathway placement
Cascade stepThromboxane amplification
Confidencehigh
RationaleCyclooxygenase-2 catalyzes thromboxane-A2 synthesis amplifying platelet aggregation.
Also acts inVascular inflammation, Platelet activation
Druggability
DruggableYes
Known drugs / candidates79
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000073756

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
52
E — evidence strength
18
T1DI (composite)
2
Specificity differential (R−C)-51.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 2/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 3 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.606
Open Targets association (myocardial_infarction)

Literature evidence(7)