Protein tyrosine phosphatase non-receptor type 11
PTPN11geneRegulates endothelial permeability and platelet activation via phosphatase signaling.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleSHP2; endothelial signaling; modulates PECAM-1 and platelet interactions.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000179295
Type I vs non-Type I discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I37
C — non-Type-I61
A — assay feasibility52
E — evidence strength24
T1DI (composite)5
Specificity differential (R−C)-23.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.483
Open Targets association (myocardial_infarction)
1
GWAS associations
Traits: myocardial infarction
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.