PVRL2

PVRL2gene

PVRL2 regulates apolipoprotein C-III expression and plasma triglyceride levels, modifying coronary disease risk.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencemedium

RationaleLipid-metabolism gene; APOC3 regulatory locus associated with plasma lipids and CAD risk.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable