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Glycogen Phosphorylase BB
Pathway / Myocardial injury (shared endpoint)

Glycogen Phosphorylase BB

PYGBprotein

PYGB (glycogen phosphorylase BB) is released during myocardial ischemia and necrosis, marking acute cardiomyocyte injury.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCardiomyocyte enzyme released during myocardial ischemia/necrosis; early injury marker.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000100994

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)