Ras-Related Protein Rab-7a
RAB7AgeneRAB7A dysregulation affects intracellular trafficking and inflammatory response in MI cells.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleSmall GTPase regulating endosomal trafficking; roles in cellular stress and autophagy.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Identification of an 11 immune-related gene signature as the novel biomarker for acute myocardial infarction diagnosis.Genes and immunity · 2022 · PMID 36182975 · doi