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Renin
Pathway / Off-pathway / systemic markers

Renin

RENprotein

Renin elevation reflects renin-angiotensin system activation and systemic hemodynamic/inflammatory stress during infarction.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleRenin-angiotensin system component; systemic marker linked to infarct size and thrombosis independent of atherothrombotic cascade.
Also acts inCoagulation / thrombus
Druggability
DruggableYes
Known drugs / candidates4
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000143839

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
61
A — assay feasibility
72
E — evidence strength
46
T1DI (composite)
9
Specificity differential (R−C)-46
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 1
3hypovolemia / dehydrationmag 2
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 3
7high-demand / peri-operative stressmag 1
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 14 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(6)

Clinical trials(2)