Resistin
RETNproteinResistin promotes atherosclerotic inflammation and lipid dysregulation, increasing Type 1 MI recurrence risk.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleAdipokine promoting monocyte recruitment and inflammatory lipid-profile dysregulation in atherosclerosis.
Also acts inLipid entry/oxidation, Systemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000104918
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I53
C — confounder / Type-II76
A — assay feasibility68
E — evidence strength29
T1DI (composite)8
Specificity differential (R−C)-23.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Restricted T-Cell Repertoire in the Epicardial Adipose Tissue of Non-ST Segment Elevation Myocardial Infarction Patients.Frontiers in immunology · 2022 · PMID 35880176 · doi
- Adipokines and endothelial dysfunction in acute myocardial infarction and the risk of recurrent cardiovascular events.Journal of cardiovascular medicine (Hagerstown, Md.) · 2015 · PMID 24933198 · doi
Clinical trials(1)
- Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and PrognosisNCT03377465 · NA · COMPLETED · ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin