CoronaryAtlas logo
CoronaryAtlas
S100A12
Pathway / Plaque inflammation

S100A12

S100A12protein

S100A12 is a core plaque-rupture and vascular inflammation marker shared across atherothrombotic events; modulates MMP activity and immune activation in MI pathogenesis.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleS100A12 drives vascular inflammation and plaque rupture; inhibits MMPs yet marks instability.
Also acts inCap degradation / rupture
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000163221

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
40
C — confounder / Type-II
66
A — assay feasibility
68
E — evidence strength
25
T1DI (composite)
6
Specificity differential (R−C)-25.8
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(3)