Syndecan-1
SDC1proteinSyndecan-1 shedding from damaged endothelium marks endothelial activation and erosion-driven Type 1 MI pathogenesis.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleGlycocalyx shedding marker; endothelial damage in ACS.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000115884
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I56
C — confounder / Type-II84
A — assay feasibility72
E — evidence strength31
T1DI (composite)8
Specificity differential (R−C)-28.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(4)
- Novel biomarkers in the prognosis of patients with atherosclerotic coronary artery disease.Revista portuguesa de cardiologia · 2020 · PMID 33239161 · doi
- Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome.Atherosclerosis · 2016 · PMID 26926597 · doi
- Association between sympathoadrenal activation, fibrinolysis, and endothelial damage in septic patients: a prospective study.Journal of critical care · 2014 · PMID 24581948 · doi
- Acute myocardial infarction is associated with endothelial glycocalyx and cell damage and a parallel increase in circulating catecholamines.Critical care (London, England) · 2013 · PMID 23433357 · doi