Semaphorin-3B

SEMA3Bprotein

Pericoronary SEMA3B dysregulation drives vascular inflammation and endothelial dysfunction contributing to atherosclerotic plaque development.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleAdipokine from pericoronary fat; dysregulation promotes vascular inflammation and endothelial dysfunction in CAD.

Also acts inEndothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000012171

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)