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Sex hormone-binding globulin
Pathway / Off-pathway / systemic markers

Sex hormone-binding globulin

SHBGprotein

SHBG is a systemic CAD-risk modifier that regulates sex-hormone bioavailability and influences metabolic and vascular health independent of atherothrombotic cascade steps.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSystemic CAD risk modifier; endocrine/metabolic axis; not direct cascade step.
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
59
C — non-Type-I
57
A — assay feasibility
68
E — evidence strength
26
T1DI (composite)
9
Specificity differential (R−C)+2.5
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)