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Sirtuin 1
Pathway / Plaque inflammation

Sirtuin 1

SIRT1protein

SIRT1 deacetylates NF-κB to suppress plaque inflammation and prothrombotic signaling, while preventing oxidized-LDL-induced endothelial dysfunction and cardiomyocyte injury.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleNF-κB inhibitor; suppresses NLRP3 and prothrombotic phenotype; cardioprotective.
Also acts inLipid entry/oxidation, Myocardial injury
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000096717

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
63
A — assay feasibility
72
E — evidence strength
15
T1DI (composite)
3
Specificity differential (R−C)-48
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 1
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 2
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 9/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.019
Open Targets association (STEMI)

Literature evidence(6)

Clinical trials(1)