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Superoxide Dismutase 1
Pathway / Lipid retention & oxidation

Superoxide Dismutase 1

SOD1protein

SOD1 catalyzes superoxide dismutation, reducing oxidative stress and preventing LDL oxidation that would otherwise accelerate plaque lipid-core expansion.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleROS-scavenging enzyme; protects against LDL oxidation in atherosclerosis.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000142168

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
0
C — confounder / Type-II
60
A — assay feasibility
72
E — evidence strength
42
T1DI (composite)
6
Specificity differential (R−C)-60
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(2)