Specificity Protein 1
SP1proteinSP1 transcriptional regulation of inflammatory and lipid-metabolism genes in atherosclerotic plaque cells.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleTranscription factor regulating inflammatory genes and lipid metabolism in plaque.
Also acts inLipid entry/oxidation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000185591
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I58
C — confounder / Type-II89
A — assay feasibility68
E — evidence strength33
T1DI (composite)8
Specificity differential (R−C)-30.3
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- Oxidized LDL Induces Pro-Inflammatory Transcriptomic and Epigenomic Responses in Human CD4T Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · PMID 41707046 · doi