CoronaryAtlas logo
CoronaryAtlas
Signal Transducer and Activator of Transcription 3
Pathway / Plaque inflammation

Signal Transducer and Activator of Transcription 3

STAT3protein

STAT3 activation by IL-10 restrains macrophage-driven plaque inflammation and vascular endothelial activation, reducing atherosclerotic destabilization.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleIL-10 responsive transcription factor; anti-inflammatory pathway regulator; suppresses plaque inflammation and endothelial dysfunction.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000168610

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
50
A — assay feasibility
72
E — evidence strength
50
T1DI (composite)
12
Specificity differential (R−C)-35
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 1
2hypovolemia / dehydrationmag 1
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 1
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 6/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 8 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(4)