TCF21

TCF21gene

TCF21 controls smooth-muscle-cell differentiation and plaque-remodeling capacity in coronary disease.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencemedium

RationaleSMC-specific transcription factor; CAD risk via smooth-muscle function and remodeling.

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000118526

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

0.522

Open Targets association (myocardial_infarction)

GWAS associations

Traits: myocardial infarction