Transmembrane and Tetratricopeptide Repeat Containing 2
TMTC2proteinTMTC2 modulates intracellular cholesterol trafficking and endothelial barrier integrity, influencing lipid retention and vascular dysfunction.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleCholesterol homeostasis and vascular endothelial function regulator; affects lipid metabolic pathways.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000179104
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)