Transmembrane Activator and Calcium-Modulator and Cyclophilin Ligand Interactor

TNFRSF13Bprotein

TACI mediates B-cell activation and immunoglobulin production; altered TACI signaling affects adaptive immunity in plaque inflammation and correlates with myocardial injury.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleTNF-receptor superfamily member; B-cell and immune activation in plaque.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000240505

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)

Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction.
Scientific reports · 2020 · PMID 33122738 · doi