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Cardiac troponin I
Pathway / Myocardial injury (shared endpoint)

Cardiac troponin I

TNNI3protein

Cardiac troponin I is released from damaged cardiomyocytes following myocardial ischemia and necrosis and is the gold-standard biomarker for acute MI diagnosis, prognosis, and risk stratification.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleCardiac contractile protein released upon myocardial necrosis; primary biomarker for AMI diagnosis and risk stratification.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000129991

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
100
C — confounder / Type-II
58
A — assay feasibility
96
E — evidence strength
78
T1DI (composite)
62
Specificity differential (R−C)+65.7
Direct evidence: higher in Type I (D=+2)
hs-cTnI: 1.4 ± 5.1 ng/L in T1MI vs 0.5 ± 1.1 ng/L in T2MI (P = 0.030)
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 1
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 13 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
High-sensitivity chemiluminescent/ECL sandwich immunoassay
Reagent / substrate
Paired anti-cTnI monoclonal antibodies (capture+detection), acridinium/ruthenium label
Platform
Automated core-lab analyzer (Abbott Architect/Alinity, Siemens Atellica, Roche cobas); Abbott i-STAT POC
Turnaround · availability
STAT (~15–60 min) · FDA-cleared, universal

Human genetic evidence

0.269
Open Targets association (acute_MI)

Literature evidence(60)

Showing 40 of 60 linked references.

Clinical trials(2)