Tumor Protein p53

TP53protein

p53 promotes ferritinophagy-driven iron metabolism during myocardial ischemia and contributes to cardiomyocyte death and plaque instability.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleMediates ferritinophagy in myocardial injury; implicated in plaque rupture and cardiomyocyte apoptosis.

Also acts inCap degradation / rupture, Vascular inflammation

Druggability

DruggableYes

Known drugs / candidates9

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000141510

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)