Triosephosphate Isomerase 1
TPI1proteinTPI1 release marks cardiomyocyte damage during acute ischemia and ischemia-reperfusion injury in MI.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleGlycolytic enzyme released during ischemic myocardial injury and ferroptosis.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000111669
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Single-cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia-reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024 · PMID 39520298 · doi
- Discovery of potential plasma protein biomarkers for acute myocardial infarction via proteomics.Journal of thoracic disease · 2019 · PMID 31656670 · doi