TRIOBP
TRIOBPproteinTRIOBP interacts with JCAD to stabilize endothelial stress fibers, preserving or modulating endothelial barrier integrity during atherosclerosis progression.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleJCAD interactor stabilizing endothelial stress fibers.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000100106
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.European heart journal · 2019 · PMID 31539914 · doi