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Urotensin II
Pathway / Off-pathway / systemic markers

Urotensin II

UTS2peptide

Vasoactive peptide modulating vascular tone and inflammatory signaling in coronary disease.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationalePotent vasoconstrictor with systemic hemodynamic and inflammatory effects in atherosclerosis.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
35
C — non-Type-I
55
A — assay feasibility
66
E — evidence strength
22
T1DI (composite)
6
Specificity differential (R−C)-20.5
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(3)