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sVCAM-1
Pathway / Endothelial activation & erosion

sVCAM-1

VCAM1protein

Soluble VCAM-1 is an endothelial adhesion molecule upregulated during endothelial activation and dysfunction; it mediates leukocyte recruitment into atherosclerotic plaques and correlates with endothelial erosion and thrombotic complications.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleEndothelial adhesion molecule; activated in response to endothelial injury and inflammation; mediates monocyte recruitment.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000162692

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
60
A — assay feasibility
68
E — evidence strength
43
T1DI (composite)
8
Specificity differential (R−C)-45
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 1
7high-demand / peri-operative stressmag 2
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 6 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-VCAM-1 (CD106) antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research

Literature evidence(44)

Showing 40 of 44 linked references.