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sVCAM-1
Pathway / Endothelial activation & erosion

sVCAM-1

VCAM1protein

Soluble VCAM-1 is an endothelial adhesion molecule upregulated during endothelial activation and dysfunction; it mediates leukocyte recruitment into atherosclerotic plaques and correlates with endothelial erosion and thrombotic complications.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleEndothelial adhesion molecule; activated in response to endothelial injury and inflammation; mediates monocyte recruitment.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000162692

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
63
A — assay feasibility
68
E — evidence strength
43
T1DI (composite)
8
Specificity differential (R−C)-48.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 1
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 2
4bstent thrombosismag 2
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 10/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA
Reagent / substrate
Anti-VCAM-1 (CD106) antibody pair
Platform
ELISA plate
Turnaround · availability
Research · Research

Literature evidence(44)

Showing 40 of 44 linked references.