Vitamin K epoxide reductase complex subunit 1
VKORC1geneCofactor for gamma-carboxylation of coagulation factors; systemic lipid/nutrient metabolism, not atherothrombotic mechanism.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleVitamin K metabolism; regulatory only, not atherothrombotic cascade.
Druggability
DruggableYes
Known drugs / candidates7
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000167397
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I74
C — confounder / Type-II37
A — assay feasibility52
E — evidence strength27
T1DI (composite)10
Specificity differential (R−C)+37.2
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.535
Open Targets association (myocardial_infarction)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.